1H-MRS in frontal lobe and hippocampus of patients with first episode major depression
- VernacularTitle:首发重性抑郁症患者双侧额叶和海马的磁共振质子波谱成像
- Author:
Xiancang MA
;
Yan SUN
;
Chengge GAO
;
Qinli SUN
;
Hui DING
;
Bolang YU
- Publication Type:Journal Article
- Keywords:
first episode major depression;
proton magnetic resonance spectroscopy;
frontal lobe;
hippocampus
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To measure metabolism in brain of first episode major depression patients with 1H-MRS.Methods Single-voxel proton magnetic resonance spectroscopic(1H-MRS) examination of bilateralis frontal lobe and hippocampus was conducted in 23 patients with first episode major depression and 23 age-,sex-and education-matched healthy controls.We examined the metabolism such as NAA,Cho,Cr,Glx and mI in bilaterlis frontal lobe and hippocampus of patients.Results Bilateralis frontal lobe NAA/Cr,right frontal lobe Glx/Cr and left hippocampus NAA/Cr and Glx/Cr were significantly lower in MD patients versus controls,but right frontal lobe and right hippocampus mI/Cr significantly higher than in controls.Conclusion Nerve cell activity disorder,abnormal second messenger and glutamicacid and glutamine may be involved in the pathogenesis of major depression.
