Expression and significance of vascular endothelial growth factor-C,VEGFR-3 and podoplanin in tissue of esophageal cancer
- VernacularTitle:VEGF-C、VEGFR-3和podoplanin在食管癌中的表达及其意义
- Author:
Wei ZHANG
;
Zhuoqi JIA
;
Bin ZHOU
- Publication Type:Journal Article
- Keywords:
esophageal cancer;
lymphatic metastasis;
VEGF-C;
VEGFR-3;
podoplanin
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of vascular endothelial growth factorC(VEGF-C),its receptor3(VEGFR-3) and podoplanin in tissue of esophageal cancer,and the relationship between their expression and tumor lymphatic metastasis.Methods Expression of VEGF-C,VEGFR-3 and podoplanin in 76 cases of ESC was detected by immunohistochemical SP method and lymphatic vessel density(LVD) was calculated.Results Positive immunostaining of VEGF-C in esophageal cancer tissue was 63.1%;the expression of VEGF-C was significantly associated with the depth of lymph node metastasis and tumor invasion(P
