Gene expression of tyrosine kinase receptor pathway in primary glioblastoma and its significance
- VernacularTitle:酪氨酸激酶受体通路相关基因在原发胶质母细胞瘤中的表达及其意义
- Author:
Liusong YANG
;
Jin HU
;
Liangfu ZHOU
;
Minhua SHAO
;
Daru LU
- Publication Type:Journal Article
- Keywords:
primary glioblastoma;
MAPK pathway;
TKR pathway;
real-time PCR
- From:China Oncology
1998;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose:Glioblastoma is one of the most common intracranial tumors, the morbidity and mortality are both high, and the molecular biological mechanism of the disease is still unclear. In this study, we detected the gene expression of tyrosine kinase receptor (TKR) pathway in primary glioblastoma(GBM) with low-density array, furthermore we analyzed the significance of the gene expression change. Methods:We detected 26 genes of RTK pathway in 10 primary GBM tissues and 9 normal brain tissues (gained from the decompression operation of brain trauma), and analyzed the different expressions of these two kinds of tissues by statistic method.Results:The Ct values of MAP2K1 and MAP2K4 in normal brain tissues were 1.6?1.7 and 2.2?2.1, the Ct values of MAP2K1 and MAP2K4 in primary GBM tissues were 3.9?1.5 and 5.0?2.0, and the Ct different values between normal brain tissues and primary GBM tissues of both genes were -2.3 and -2.8(P
