The research progress of carcino-embryonic antigen related cellular adhesion molecule 1
- VernacularTitle:癌胚抗原相关细胞黏附分子1(CEACAM1)的研究进展
- Author:
Chengqiang JIN
;
Fang LIU
;
Wenjuan WANG
- Publication Type:Journal Article
- Keywords:
carcino-embryonic antigen related cellular adhesion molecule 1;
T lymphocyte;
tumor
- From:China Oncology
1998;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Carcino-embryonic antigen related cellular adhesion molecule 1(CEACAM1),used to be called CD66a, biliar glyeoprotein(BGP) or C-CAM,is a glucoprotein expressed on the surface of cells, a member of the carcino-embryonic antigen family(CEA) and an adhesion molecule of immunoglobulin superfamily. It is widely expressed on the epithelial cells and vascular endothelial cells.CEACAM1 inhibits tumor growth and epithelial cell proliferation, induces apoptosis of epithelial cells, inhibits activation and proliferation of T lymphocytes, stimulates proliferation of B lymphocytes, inhibits the cytotoxic effects of T cells and NK cells, delays apoptosis of granulocytes and monocytes, inhibits the activity of tumor-infiltrating lymphocytes, stimulates invasion of tumor cells and motility of endothelial cells, promotes blood vessel angiogenesis, and modulates vascular remodeling, so it has many important biological functions.
