Local application of exogenous VEGF on survival of rats random flaps after radiotherapy
- VernacularTitle:局部应用外源性VEGF对放疗后随意皮瓣成活影响的实验研究
- Author:
Chunli LIU
;
Peng MA
;
Yue WANG
- Publication Type:Journal Article
- Keywords:
Random flap;
VEGF;
Radiation injury
- From:
Journal of Practical Stomatology
1996;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the local application of exogenous VEGF on survival of rats random flaps after radiotherapy.Methods:45 four-month old Wistar rats were taken as experimental objects and divided into 3 groups randomly to construct animal models of random flaps and simulated radiotherapy with 60Co radioactive source with 6 Gy,500 cGy/min.All the rats were killed 28 days after radiotherapy were carried out.The vitality of flaps was observed 7 days and 28 days after radiotherapy.Flaps were evaluated with cytological staining experiments,histopathological experiments and SDH measurements.Results:The group which applied VEGF was greatly distinguished from control groups(P
