Evaluation of Estrogenic Activity of DDE by MCF-7 Cell Proliferation Bioassay
- VernacularTitle:二氯二苯二氯乙烯的类雌激素活性的实验研究
- Author:
Ming ZHANG
;
Li DONG
- Publication Type:Journal Article
- Keywords:
Pesticides;
Environment estrogen;
Cell multiplication
- From:
Journal of Environment and Health
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the estrogen activity of DDE by using MCF-7 cell proliferation bioassay.Methods The estrogen activity of DDE was tested by using the MCF-7 cell multiplication experiment in vitro and the mechanism was explored preliminarily through growth curve analysis.Results DDE showed an obvious estrogenic activity in the MCF-7 cell proliferation and the cell cycle analysis indicated that cell proliferation index in DDE group was significantly higher than that in the control group.Conclusion DDE has the estrogenic activity and the mechanism may be the same as that of E2,that is,binding with the estrogen receptor is the first step of the following biological effects.
