Antagonism of Glutathione to Antioxidative Capacity Decrease Induced by Manganese Exposure in Rats
- VernacularTitle:谷胱甘肽对锰染毒大鼠抗氧化能力的影响
- Author:
Xianping ZHANG
;
Xiulian CAI
;
Qianxing WANG
- Publication Type:Journal Article
- Keywords:
Metal,heavy_Lipid peroxidationa Manganesea Superoxide dismutasea Glutathionea Catalasea Glutathione peroxidase
- From:
Journal of Environment and Health
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the antagonism of glutathione(GSH) to antioxidative capacity decrease induced by manganese exposure in rats.Methods 48 healthy male SD rats were randomly divided into six groups: the blank control,GSH control,MnCl2.4H2O(15 mg/kgand 30 mg/kg),15 mg/kgMnCl2.4H2O+1 mmol/kgGSH and 30 mg/kg MnCl2.4H2O+1 mmol/kg GSH,the treatment was conducted through peritoneal injection.The activity of superoxide dismutase(SOD),catalase(CAT) and glutathione peroxidase(GSH-Px)in the serumand the testis were determined bycolorimetric analysis.Results Compared with the blank control group,the activity of SOD,CAT and GSH-Px in the serum and testis in 30 mg/kg groups significantly decreased(P
