Effect of Avermectins on Expression of HSP70 mRNA in Rats Hepatic Tissue
- VernacularTitle:阿维菌素原药诱导大鼠肝组织热应激蛋白70基因表达的研究
- Author:
Mingyue ZHANG
;
Xiuying QI
;
Jing ZHANG
- Publication Type:Journal Article
- Keywords:
Pesitides;
Avermectins;
Heat shock protein;
Gene express
- From:
Journal of Environment and Health
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the expression of heat shock protein(HSP70) mRNA induced by avermectins in the hepatic tissue of rats.Methods Wistar rats aged 6 weeks were randomly divided into 4 groups,12 in each including 6 male and 6 female.The rats in the experimental groups were treated with avermectins by gavage once a day at the doses of 2.5,1.25 and 0.625 mg/kg respectively for 14 consecutive days,one group was the negative control.The general state was concerned and after the exposure,the content of total protein(TP) in the serum was determined,the hepatic tissue was sampled to examine the expression of HSP70 mRNA by polymerase chain reaction(PCR).Results The content of TP in the serum in the 2.5 mg/kg group was lower than that in the control group(P
