Protection of You-gui-wan on hydrocortisone-induced apoptosis of murine thymocytes
- VernacularTitle:右归丸对糖皮质激素诱导的胸腺细胞凋亡的保护作用
- Author:
Yuqi GUO
;
Xianbin ZHOU
;
Li WANG
;
Yang LIU
;
Chengfang YAO
- Publication Type:Journal Article
- Keywords:
You-gui-wan;
Hormone;
Anei-apoptosis;
Bcl-2;
Bax
- From:
Chinese Journal of Immunology
1985;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the protective mechanisms of You-gui-wan on hydrocortisone-induced apoptosis of murine thymocytes.Methods:Annexin V/ PI double stain was applied to analyze the apoptotic states of thymocytes after injection with hydrocortisone coupled with or without administration You-gui-wan.The transcriptions of Bcl-2 and Bax were tested by RT-PCR.Results:The apoptotic rate of thymocytes was seriously increased in hydrocortisone-injected mice contrasted to matched control mice(P
