Expression level of osteopotin and lupus nephritis
- VernacularTitle:单核细胞骨调素的表达水平与狼疮肾炎
- Author:
Ruixia MA
;
Qi SONG
;
Xianghua WANG
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
Osteopontin;
Lupus nephritis
- From:
Chinese Journal of Immunology
1985;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the role of osteopotin in lupus nephritis (LN).Methods:Sera osteopotin( OPN )levels were measured by enzyme linked immunosorbent assay in 90 patients with systemic lupus erythematosus (SLE),15 non-SLE patients with renal impairment,and 30 healthy volunteers.OPN mRNA expression in peripheral blood mononuclear cells (PBMCs) was also investigated with reverse transcription-polymerase chain reaction semi-quantitative method.Results:The expression of OPN was significantly higher in active LN groups than in all other groups(P0.05).Conclusion:The expression of PBMCs OPN mRNA is up regulation in active SLE.Meanwhile,its expression levels are correlated with the activity of LN.
