Expression and significance of Glut1 and HIF-1? in human hepatocellular carcinoma
- VernacularTitle:肝癌组织中Glut1与HIF-1?基因蛋白表达及意义
- Author:
Hui LIANG
;
Kefeng DOU
- Publication Type:Journal Article
- Keywords:
human hepatocellular carcinoma;
Glut1;
HIF-1?;
immunohistochemistry;
prognosis
- From:
China Oncology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose:Glut functioning as a vehicle for transferring glycose into cell,plays an important role in strengthening the glycometabolism process of malignant tumor.HIF-1?,a crucial transcriptional control gene in signaling cell to adapt to anaerobic microenvironment,can activate the expression of many anaerobic-responding genes which includes the expression of Glut1 gene,in order to supply energy for tumor under hypoxia.Our aim was to investigate the expression and clinical significance of Glut1 protein and HIF-1? protein as well as the correlation between them in human hepatocellular carcinoma(HCC). Methods :Immunohistochemical staining: EnVision method was used to detect the expression of Glut1 and HIF-1? in 45 cases with human hepatocellular carcinoma,and in 11 cases with normal hepatic tissue. Results :The positive expression rate of Glut1(66.7%) and HIF-1?(73.3%) in human hepatocellular carcinoma was higher than that in normal hepatic tissue(P
