A Study on Arrenotokous Toxic Action of Diphenylmethane Diisocyanate and Its Mechanism
- VernacularTitle:二苯基甲烷二异氰酸酯对雄性小鼠的生殖毒性及其机制研究
- Author:
Jinpeng ZHOU
;
Jie LI
;
Dafeng LIN
- Publication Type:Journal Article
- Keywords:
Diphenylmethane diisocyanate;
Fertility;
Toxic action;
Mechanism
- From:
Journal of Environment and Health
1992;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the arrenotokous toxic action and the related mechanism of MDI in mature male KM mice. Methods The 8-month-old healthy KM mice were intraperitoneally injected with MDI maize oil solution at the dose of 0、62.5、125.0、250.0 mg/kg in normal control group and 3 experiment groups respectively for 14 days.The male mice were killed on day 15 for the measurement of the viscera coefficient of testis and epididymis, the sperm count in epididymis, the activities of enzymes of testis,and concentration of related hormone in testis and blood serum. Results There was no significant difference in body weight between the experiment and the control groups. The viscera coefficient of testis and epididymis in 250.0 mg/kg group decreased significantly compared with the control group(P
