Effect of astragalus polysaccharides on the cellular immune function in rats with sciatic nerve Wallerian degeneration
- VernacularTitle:黄芪多糖对坐骨神经华勒变性大鼠细胞免疫功能的作用研究
- Author:
Qiuling SANG
;
Biao LIU
;
Zhuang WEI
;
Weitian YIN
- Publication Type:Journal Article
- Keywords:
Astragalus polysaccharides;
Wallerian degeneration;
Sciatic nerve;
Immune regulation;
IL-1?
- From:
Chinese Journal of Immunology
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of astragalus polysaccharides on the cellular immune functions in rats with sciatic nerve Wallerian degeneration.Methods:10 female Wister rats were established as the sciatic nerve injury model,which were randomly divided into astragalus polysaccharides group and control group.Then 20 mg/kg of astragalus polysaccharides were peritoneal injected every postoperative day in experimental group for 7 days and the same volume of saline for the control group.The content of IL-1? in serum and in supernatants of spleenocytes and macrophages was measured by Sandwich ELISA.Results:The proliferation ability of splenic T cells and macrophages in astragalus polysaccharides group was higher than that of control group(P0.05).Conclusion:Astragalus polysaccharides induces the cellular immuno-regulation in sciatic nerve Wallerian degeneration rats and by this way to promote nerve regeneration.
