Relationship between Environmental Endocrine Disruptors, Genetic Polymorphism of Related Metabolic Enzymes and Breast Cancer
- VernacularTitle:环境内分泌干扰物及代谢酶基因多态性与乳腺癌的关系
- Author:
Yongli CHANG
;
Jun LI
- Publication Type:Journal Article
- Keywords:
Environmental endocrine disruptor chemicals;
Genetic polymorphism;
Breast cancer
- From:
Journal of Environment and Health
1992;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer is one of reproduction-endocrine related tumors, so the risk factors including environmental and genetic factors which can disrupt anabolism and function of estradiol may increase the risk of breast cancer. Persistent environmental endocrine disruptor chemical (EDCs) can disrupt anabolism and function of endogenous hormone and the degree of disruption may depend on genetic polymorphism. EDCs and metabolic enzyme genetic polymorphism were discussed in this paper. To study the risk factors of breast cancer, both of the environmental factors and the genetic factors should be included.
