Advances in effects and mechanisms of ADAMs in tumor progression
- VernacularTitle:ADAMs在肿瘤发展中的作用及其机制研究进展
- Author:
Qin CHEN
;
Linghua MENG
;
Jian DING
- Publication Type:Journal Article
- Keywords:
ADAMs;
EGFR signaling;
tumor metastasis;
angiogenesis
- From:
China Oncology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
ADAMs is a family of transmembrane proteins with multi domains and multiple functions,which play important roles in many(patho-)physiological processes.They are upregulated in a variety of tumors and possess protein shedding and adhesive activities,which showed that they could be useful as tumor biomarkers and promising targets for designing new anti-tumor drugs.This review focuses on the roles ADAMs play in the process of tumor development and the potential application in cancer therapy.
