Signal pathway of CYLD and tumor
- VernacularTitle:CYLD信号通路与肿瘤
- Author:
Junjie WU
;
Qiang LI
- Publication Type:Journal Article
- Keywords:
CYLD;
cylindromatosis;
NF-?B;
JNK;
Bcl-3
- From:
China Oncology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Tumor suppressor CYLD is a deubiquitination enzyme that could regulate NF-?B and JNK signal pathways by deubiquitinating TRAFs,NEMO,Bcl-3 and p53,and in turn regulating the cell cycle and apoptosis.Loss or deficiency of CYLD would lead to the development of skin tumor,including multiple familial trichoepithelioma(MFT),familial cylindromatosis(FC),Brooke-Spiegler syndrome(BSS).Cancers like uterine cervix,kidney,and colon and hepatocellular carcinoma are related to the down-regulation of CYLD.
