Expression of CD44V6,?-catenin in osteosarcoma and its clinical significance
- VernacularTitle:细胞黏附分子在骨肉瘤中的表达及其临床意义
- Author:
Chengcun LI
;
Dong ZHANG
;
Min LI
- Publication Type:Journal Article
- Keywords:
CD44V6;
?-catenin;
osteosarcoma;
invasion;
neoplasm metastasis
- From:
Orthopedic Journal of China
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objeetive] To compare the expression level of CD44V6,?-catenin in osteosarcoma cells with controls,and to investigate the correlation with invasion of osteosarcoma cells.[Methods]Expression of CD44V6 and ?-catenin was examined by immunohistochemistry SP method in 35 specimens of human osteosarcoma tissue.The control group was 15 samples of normal bone tissue and 15 samples of osteochondroma.[Results]The expression of CD44V6 and ?-catenin was correlated significantly with clinical stage,neoplasm metastasis(P0.05).In osteosarcoma,CD44V6 was positively correlated with the expression of ?-catenin(u=3.77,P
