Effect of compressive stress on expression of CTGF in rabbit mandibular condylar chondrocytes in vitro
- VernacularTitle:压应力对体外培养兔髁突软骨细胞CTGF基因表达的影响
- Author:
Bin HAN
;
Hui CHEN
;
Jie LI
- Publication Type:Journal Article
- Keywords:
Mandibular condylar chondrocyte;
Compressive stress;
Connective tissue growth factor
- From:
Journal of Practical Stomatology
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect of compressive stress on expression of connective tissue growth factor(CTGF) in rabbit mandibular condylar chondrocytes in vitro. Methods:CTGF mRNA were determined by semiquantitative RT-PCR in rabbit mandibular condylar chondrocytes cultured in vitro. Results:Within a certain compressive stress, CTGF mRNA were up-regulated with the increase of compressive stress. While under certain compressive stress, CTGF mRNA were gradually up-regulated following the increase of culturing time, and reaching the maximum at 2~6 h, then gradually down-regulated until at 24 h. Conclusion:Application of different compressive stresses can up-regulate the expression of CTGF mRNA in rabbit mandibular condylar chondrocytes. It may be involved in the stress -mediated mandibular condylar cartilage remodeling.
