Chronic Toxic Effect of Herbicide Mixture on Mice Hepatic Function and Ultrastructure
- VernacularTitle:混合除草剂对小鼠肝功能及其超微结构的慢性毒性作用
- Author:
Guijuan WANG
;
Huizhen WU
;
Guisheng LIU
- Publication Type:Journal Article
- Keywords:
Herbicide;
Mice;
Liver;
Serum transaminase;
Ultrastructure
- From:
Journal of Environment and Health
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the chronic hepatotoxicity of the commonly used herbicide mixture in the mice. Methods Low doses herbicide mixture diluted in mice drinking water. The parameters related to hepatic function and ultrastructural changes of the hepatocytes were examined after 18 weeks and 24 weeks of treatment. Results No changes was observed in every parameter after 18 weeks of treatment compared with the control group. After 24-week of treatment, the electron microscope revealed the ultrastructural changes in the hepatocytes, rough endoplasmic reticulum showed dilatation, mitochondria showed matrix muddy with distortion and disappearance of inner crista and the serum transaminase were higher than those in the control group(P
