Default-mode Activation Network in Hepatic Cirrhosis: A fMRI Study
- VernacularTitle:肝硬化病人脑默认功能网络的功能磁共振成像研究
- Author:
Longjiang ZHANG
;
Jianzhong YIN
;
Ji QI
- Publication Type:Journal Article
- Keywords:
liver;
cirrhosis;
functional magnetic resonance imaging(fMRI);
default mode
- From:
Journal of Practical Radiology
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore resting state network in patients with hepatic cirrhosis using functional magnetic resonance imaging(fMRI).Methods 14 patients with hepatic cirrhosis and 14 healthy volunteers were included in this study.Modified Stroop task in Chinese character was used as target stimulus,block-design fMRI was used to acquire resource data.Group analysis(control epoch minus task epoch) was performed for both tasks in both groups.Results Comparing with controls,the patients with hepatic cirrhosis had abnormal deactivation mode.The absence of posterior cingulate cortex(PCC) and precuneus was present when performing incongruous word-reading task,deactivation of PCC,precuneus,and ventral medial prefrontal cortex were increased when performing incongruous color-naming task.Conclusion Cirrhosis patients have abnormal deactivation mode,the absence of PCC and precuneus is a sensitive not specific biomarker in detecting the brain changes of the patients with hepatic cirrhosis.
