The Relationship between Brain Atrophy and Change of Corpus Callosum Area in Patients with Cerebral Vascular Disease
- VernacularTitle:脑血管病患者脑萎缩率与胼胝体面积变化率的关系
- Author:
Sheng XIE
;
Jiangxi XIAO
;
Wei WANG
;
Yining HUANG
;
Xuexiang JIANG
- Publication Type:Journal Article
- Keywords:
brain;
MRI;
brain atrophy;
cerebral vascular disease
- From:
Journal of Practical Radiology
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To estimate relationship between the brain atrophy rate and percent corpus callosum area change in patients with cerebral vascular disease.Methods Forty-six patients with cerebral vascular disease underwent MR scanning twice,at the baseline and at the end of the follow-up period.T1W images at both time points were processed automatically with structural image evaluation using normalization of atrophy(SIENA) software to determine the percent brain volume change(PBVC).In addition,the corpus callosum and the inner table of the skull on the mid-sagittal images of two scans were outlined manually to measure their areas.The percent of corpus callosum area change(PCCAC) was calculated.Then,the relationship between PBVC,PCCAC and age was statistically analyzed.Results Significant correlation was found among the three variables: spearman rank correlation coefficient was-0.295 for PBVC and age(P=0.047),while it was-0.4 for PCCAC and age(P=0.006),and 0.538 for PBVC and PCCAC(P=0.000).Conclusion SIENA software identifies brain atrophy quantitatively in patients with cerebral vascular disease,which correlated with area reduction of the corpus callosum.
