Effects of Vitamin E on Mouse Lung Cancer Induced by Benzo(a)pyrene
- VernacularTitle:维生素E对苯并(a)芘所致小鼠肺癌的干预作用
- Author:
Jie YANG
;
Yufei ZHENG
;
Zhaoli CHEN
- Publication Type:Journal Article
- Keywords:
Vitamin E;
Benzo(a)pyrene;
Lung cancer
- From:
Journal of Environment and Health
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The epidemiologic evidences indicate that the benefits of using vitamin E (VE) against lung cancer remain controversial, the goal of the present paper is to know whether VE can produce the protective effect in lung cancer induced by benzo(a)pyrene B(a)P . Methods 225 Swiss mice were randomly divided into groups and treated with B(a)P and VE to systematically observe the intervention effects of VE on mouse lung cancer caused by B(a)P. Results VE exhibited no protective effect on B(a)P-induced lung cancer in female mice and instead promoted B(a)P carcinogenesis; neither protective effect nor promotion effect was observed in the male mice. The mechanism by which VE intervention influenced B(a)P carcinogenesis and lung cancer in female mice might be more complex. Conclusion The results of the present paper suggest that VE should not be used to prevent lung cancer induced by B(a)P.
