Effects of iodine deficiency and iodine excess on thyroid function and structure in rats
- VernacularTitle:碘缺乏和碘过多对大鼠甲状腺结构与功能的影响
- Author:
Xiuling NIE
- Publication Type:Journal Article
- Keywords:
Iodine deficiency;
Iodine excess;
Iodine tolerance;
Hypothyroidism
- From:
Chinese Journal of Endocrinology and Metabolism
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of iodine deficiency and excess on thyroid function and structure were observed in rats.Urinary iodine,iodine in thyroid and thyroid hormones in serum and thyroid tissue of the rats with low iodine intake were significantly lower than those in rats with normal iodine intake.Urinary iodine and iodine content in thyroid increased gradually,however,thyroid hormones in serum and thyroid tissue decreased with excessive iodine intake.Thyroid follicles in the low iodine intake group showed hyperplasia under light microscope.Thyroid follicles showed polymorphic changes in 5-and 10-fold excessive iodine intake groups and significant hyperplasia in 50-and 100-fold excessive iodine groups.These findings suggest that both iodine deficiency and iodine excess can cause hypothyroidism.
