Impact of the CD4~+CD25~(nt/hi)CD127~(lo) regulatory T cells on the immune status and disease progression in HIV-1 infected individuals
- VernacularTitle:CD4~+CD25~(nt/hi)CD127~(lo)调节性T细胞对HIV感染者免疫状态及病程进展的影响
- Author:
Mingkui ZHOU
;
Yile XUE
;
Juli GONG
;
Leiming ZHOU
;
Xiaohong ZHENG
;
Jing GAI
;
Fangwei SHEN
;
Wei ZHANG
;
Zhen NING
;
Qing YUE
;
Wei LU
;
Qichao PAN
;
Laiyi KANG
;
Ping ZHONG
;
Wensi ZHU
;
Ying WANG
- Publication Type:Journal Article
- Keywords:
HIV-1;
CD4+CD25+ regulatory T cell;
CD127;
ELISpot;
IFN-?
- From:
Chinese Journal of Immunology
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the impact of the CD4+CD25nt/hiCD127lo regulatory T cell subset frequency on the immune status and disease progression of Chinese HIV-1 infected individuals.Methods:83 untreated HIV-infected individuals and 312 healthy control individuals of four distinct age groups were enrolled in the research. The CD4+ T cell absolute counts, phenotypes and frequency determination of CD4+CD25nt/hiCD127lo Regulatory T cell subsets was performed on freshly obtained whole blood samples by 3-color immune staining flow cytometry. The HIV-1 specific cellular immune function was test at single cell level by ELISpot. The corresponding plasma viral load was determined by NASBA.Results:The frequency of peripheral CD4+CD25nt/hiCD127lo regulatory T cells of HIV infected individuals in distinct disease progression status was dissimilar in China , and significantly increased in contrast to the healthy controls(P
