Progression on response and prognosis of lung cancer and single nucleotide polymorphism
- VernacularTitle:单核苷酸多态性与肺癌化疗疗效及预后相关研究进展
- Author:
Ju LIU
;
Binghe XU
- Publication Type:Journal Article
- Keywords:
single nucleotide polymorphism;
lung cancer;
response;
prognosis
- From:
China Oncology
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Single nucleotide polymorphism(SNP)is the single base pair variation in genomic DNA that occurs in more than 1% of the general population.SNPs sometimes cause structural and functional changes in protein encoded by the gene.In the treatment of malignant tumors,SNPs may be key factors in determining responses and prognosis of the treatment.Main genes that have been studied on the correlation of SNP with response and prognosis after the treatment of non-small cell lung cancer include:DNA excision and repair gene,matrix metalloproteinase gene,apoptosis related gene,drug metabolism related gene,cell cycle control gene,etc.This review will focus on the advances in correlation of single nucleotide polymorphism with response and prognosis of lung cancer after chemotherapy.
