Bone defect repair using allogenic ECM combined with chondrocytes in rabbits
- VernacularTitle:ECM修复兔桡骨缺损的实验研究
- Author:
Junbin LIU
;
Xiangtong QI
- Publication Type:Journal Article
- Keywords:
bone defect;
bone grafting;
extracellular cartilage matrix(ECM);
chondrocyte
- From:
Orthopedic Journal of China
2006;0(23):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]The characteristics and mechanism of the bone defect repair with the using allogenic extracellular cartilage matrix(ECM)were studied.[Method]Forty New Zealand white rubbits were divided into three groups at random:A and B on the right side,the defect was covered with the complex of ECM and autologous mesenchymal stem cells(MSCs),the ECM in the groups A and B,respectively.The defects on the left side served as controls correspondingly.The rabbits were killed at the 2nd,4th,6th,10th week.Samples were taken for radiological and histological studies.[Result]In the experimental sides the bone defects were healed.New bone appeared in the way of intramembranous ossification and entochondrostosis.[Conclusion]It is suggested that the complex of ECM and autologous MSCs has the effects on guiding bone regeneration and preventing from nonunion.
