Study on antineo - plastic properties of cisplatin DLTW 1 on in vitro and in vivo experimental cancer model
- Author:
Tran Cong Yen
- Publication Type:Journal Article
- Keywords:
cancer, cisplatin DLTW 1
- MeSH:
Antineoplastic Agents;
Pharmaceutical Preparations;
Neoplasms
- From:Pharmaceutical Journal
2005;0(7):17-18
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
In vitro and invivo anticancer activity of cisplatin on experimantal model of cancer. In comparison with the controls, a single dose of Cisplatin of 8 mg/kg of animal body weight was injected in mouse. The preparation inhibited completely the formation of ascitic fluid in mice bearing sarcoma 180. the biomass of the sarcome was minished by 99,5%, with anti – tumor effcacy (+++) according to H. to kawa scale (1989). Cisplatin (produced by the central babrik of planta medic) blocked 68% of mitotic index of cancer cells. The increase in life span of cancer mice treated by cisplatin was 130% more than that of the controls (39,2 days versus 17 days) 70% of treated mice survived after 27 days
