Expression of cyclooxygenase-2 in primary hepatocellular carcinoma and its relationship with clinical pathological features
- VernacularTitle:环氧合酶-2在原发性肝细胞癌中的表达及其与HCC临床病理特征之间的关系
- Author:
Yaling QI
;
Yanqiu FANG
;
Xiumei DUAN
;
Yan TAN
;
Dong CHEN
- Publication Type:Journal Article
- Keywords:
COX-2;
HCC;
IHC;
FCM
- From:
Chinese Journal of Immunology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of cyclooxygenase-2 in primary hepatocellular carcinoma, in cancer surrounding tissues and normal liver tissue and its relationship with clinical pathological features.Methods:The expression of COX-2 was detected in 30 cases of hepatocellular carcinoma, 20 cases of cancer surrounding tissue and 10 normal liver tissue by flow cytometry (FCM) and immunohistochemistry (SP). The clinical data were analyzed retrospectively.Results:(1)The expression of COX-2 in the HCC tissue was significantly higher than in cancer surrounding tissues and normal liver tissue (P0.05).Conclusion:The hyperexpression of COX-2 in tissue can reflex the biological behavior of HCC,and have very important role in the development of HCC.The specificness of COX-2 protein expression make it to be new target of tumor diagnosis and treatment.These results provide a theoretical basis for the chemoprevention of hepatoma.
