Experimental Study on~1HMRS of Acute Ischemic Cerebral Infarction before and after Intra-arterial Thrombolytic Therapy in Canine Model
- VernacularTitle:急性脑梗死动脉溶栓治疗前后的质子磁共振波谱实验研究
- Author:
Yujie HE
;
Xuejian WANG
;
Qinghua WU
;
Shi ZHOU
- Publication Type:Journal Article
- Keywords:
MR spectroscopy;
brain,ischemia;
thrombolytic therapy;
canine
- From:
Journal of Practical Radiology
1992;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the applied value of proton magnetic resonance spectroscopy(1HMRS) in evaluating the canine model of acute ischemic cerebral damage and intra-arterial thrombolytic therapy.Methods 18 adult hybrid canines were all occluded with self-thromboses and randomly divided into 6 groups(three canines in each group),group B1,B3,B6,B9 and B12 were given intra-arterial thrombolytic therapy with urokinase(10,000IU/kg) at 1.5,3.5,6.5,9.5 and 12.5 hours after embolism respectively.The axial diffusion-weighted images(DWI) and 1HMRS were performed in all canines at 1,3,6,9,12 and 24 hours after embolism respectively.24 hours after embolism,one canine in every group was randomly selected to be executed pathologic examination.Results NAA,Cho and Cr decreased in non-thrombolytic group,specially NAA in the first 6 hours.Cho and Cr decreased a little,but they were not so significant compared with NAA.The relative value of Lac was persistent elevation within 24 hours.In thrombolytic group,the degree of elevation of Lac was significantly smaller than in group A(P
