Effects of Aluminium Exposure on ?-CaMKⅡ in Hippocampus of Lactational Rats
- VernacularTitle:铝暴露对哺乳期大鼠海马中钙调素依赖性蛋白激酶Ⅱ含量及活力的影响
- Author:
Fengjin HAO
;
Xin XIE
;
Xianyu PIAO
- Publication Type:Journal Article
- Keywords:
Aluminium;
Calcium-calmodulin-dependent protein kinase Ⅱ;
Learning;
Memory
- From:
Journal of Environment and Health
2007;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the mechanism of aluminum-induced damage of learning and memory by studying the change of calcium-calmodulin-dependent protein kinase Ⅱ(CaMKⅡ) in the hippocampus of lactational rats. Methods Three groups of clean pregnant Wistar rats (120-200 g) were randomly divided into 3 groups. On the first day of parturition, the dams of two groups were given 0.3% and 0.6% AlCl3 through drinking water and terminated on the weaning day (21 days). Western blot was used to determine the content and activity of ?-CaMKⅡ. Results The aluminum levels in the blood and brain of aluminum-treated rats were obviously higher than that in the control (P
