Be aware of non-classical 21-hydroxylase deficiency and improve its treatment
- VernacularTitle:提高非经典型21-羟化酶缺陷症的诊治水平
- Author:
Guang NING
- Publication Type:Journal Article
- Keywords:
Congenital adrenal hyperplasia;
21-hydroxylase deficiency,non-classical;
17-hydroxyprogesterone;
ACTH-stimulating test
- From:
Chinese Journal of Endocrinology and Metabolism
2001;0(05):-
- CountryChina
- Language:Chinese
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Abstract:
Non-classical 21-hydroxylase deficiency(21OHD)is one of the most frequent autosomal recessive hereditary disease.Non-classical 21OHD is often underdiagnosed or misdiagnosed in patients with hyperandrogenemic symptoms(such as hirsutism,acne),menstrual disorder and infertility because of its moderate symptoms and hormonal abnormalities.However,the long-term healthy risks of non-classical 21OHD,such-as insulin resistance,dyslipidemia and cardiovascular diseases are clearly elevated.Basal and ACTH-stimulated 17- hydroxyprogesterone levels are quite helpful as a screening approach in diagnosis of non-classical 21OHD. Furthermore,non-classical 21OHD can be effectively treated with low-cost,therefore we should pay great attention to the diagnosis and treatment of non-classical 21OHD.
