Immunological study on sciatic nerve transplant tolerance induced by intrathymic injection of allogenic antigen
- VernacularTitle:胸腺内注射同种异体抗原抑制坐骨神经移植排斥反应的免疫学研究
- Author:
Shuying GAO
;
Fengyun ZHANG
;
Baixiang LI
;
Liqun WANG
- Publication Type:Journal Article
- Keywords:
Intrathymic injection;
Sciatic nerve transplantation;
Immunological rejection
- From:
Chinese Journal of Immunology
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of intrathymic injection of allogenic antigen to sciatic nerve transplantation.Methods:C57BL/6(H-2b) mice were used as donors and BALB/c(H-2d) as recipients. The recipients were divided into four groups: auto-transplantation group, allogenic transplantation group, allogenic transplantation and using immunosuppressive drugs,intrathymic injection group: 3 mol/L KCl MHC antigen extractions were injected into the recipients’ thymus before two weeks before the sciatic nerves were transplanted. In the third week all the recipients underwent immunological detections for IL-2R,TNF-?,mixed lymphocytes culture and apoptosis.Results:All the detections indicated that it was of significant difference between intrathymic injection group and those in allogenic transplantation group.Conclusion:The immunological rejection of allogenic peripheral nerve transplantation can be somewhat inhibited by intrathymic injection of allogenic MHC antigen.
