Effect of Low Level Exposure of Toluene on CPP in Rats
- VernacularTitle:低剂量甲苯吸入诱导大鼠条件性位置偏爱的实验研究
- Author:
Jiajia ZUO
;
Wei SUN
;
Tianpeng YANG
- Publication Type:Journal Article
- Keywords:
Toluene;
Conditioned place preference;
Olfactory bulb;
Addiction
- From:
Journal of Environment and Health
2007;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To know the effect of low level exposure of toluene on conditioned place preference (CPP) in rats. Methods 60 SD rats were randomly divided into 6 groups, 10 in each. 4 groups were treated respectively with toluene by inspiration of 328.6, 1 026.8mg/m3, OB-impaired+toluene 328.6 mg/m3, OB-impaired+1 026.8 mg/m3 in a closed chambers for 4 weeks (5 days/week, 6 hours/day) and 2 groups were taken as the control, OB-impaired control, blank control. The addiction and the generating electricity of the OB were examined by CCP chamber and the system of PowerLab. Results Compared with the blank group, in the toluene 328.6 and 1 026.8 mg/m3 groups the time in the light chamber was longer (P
