Effect of Nitrobenzene on Reproduction System of Male Mice
- VernacularTitle:硝基苯对雄性小鼠生殖系统的影响
- Author:
Shuhua ZHAO
;
Chenxu LI
;
Dedong WANG
- Publication Type:Journal Article
- Keywords:
Nitrobenzene;
Testis;
Mice
- From:
Journal of Environment and Health
2007;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of nitrobenzene(NB) on the activity of enzymes and the content of zinc in the testis tissue of mice. Methods 40 male mice were divided into 4 groups, 10 in each, 3 groups were treated with NB at the doses of 2, 20, 200 mg/kg by gavage, the control group was treated with vegetable oil in the same volume, once a day, for 21 consecutive days. The activity of G-6-PD, LDH and the content of Zn2+ in testis cells were determined. Results The index of epididymis and testis in the groups of 200 mg/kg were significantly lower compared with the control and 2 mg/kg group (P0.05). The activity of G-6-PD, LDH and the content of Zn2+ in all the treated groups were lower than those in the control group (P
