Significance and relationship of Survivin and Caspase-3 in osteosarcoma
- VernacularTitle:骨肉瘤中Survivin与Caspase-3的表达及其相关性研究
- Author:
Yufeng WANG
;
Yanfeng WANG
;
Peixu BING
- Publication Type:Journal Article
- Keywords:
osteosarcoma;
Survivin;
Caspase-3;
apoptosis
- From:
Orthopedic Journal of China
2006;0(19):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To investigate the relationship between Survivin,Caspase-3 and cell apoptosis in osteosarcoma.[Method]The expression of Survivin and Caspase-3 in osteosarcoma were detected by immunohistoehemistry.The apoptosis of osteosarcoma cell was assessed by terminal deoxynucleotide transferase mediated dUTP nick end labeling(TUNEL).[Result]The results showed that Survivin expression was detected 77% in osteosarcoma tissues and was significantly higher than in the normal tissues.Caspase-3 was detected in 26 of 40(65%)osteosarcoma tissues and in 34 of 38(89%)in normal bone tissues,with significant difference(P
