Association of TPH gene polymorphism with major depression and symptom phenotypes
- VernacularTitle:TPH基因多态性与重性抑郁症及症状表型的相关性
- Author:
Chengge GAO
;
Yang YANG
;
Wei FU
- Publication Type:Journal Article
- Keywords:
depression;
tryptophan hydroxylase gene;
polymorphism
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association among the depression,symptom phnotypes and polymorphism TPH A218C in the Han Chinese.Methods TPH A218C was determined using a PCR-based technique.TPH was genotyped using restriction fragment length polymorphism in 70 patients affected by depression and 70 unrelated controls.We evaluated the symptom phenotypes of cases applying the Hamilton Rating Scale for depression(HAMD). Results The TPH A218C genotype distribution in 70 patients with major depression was significantly different from that in controls(?2=6.946,P=0.031).The C allele in patients(44.3%) was significantly more frequent than in controls(24.3%) but the A allele(55.7%) and A/A genotype(31.4%) were significantly less frequent than in controls(75.7% and 62.9%)(?2=6.946,P=0.031).Meanwhile,among the males,a trend was observed toward an excess of TPH C/C(12.5% vs.6.3%) in patients and excess of TPH A/A in controls(75.0% vs.25.0%)(?2=8.103,P=0.017).There were no significant differences in three genotypes distribution among symptom phenotypes of cases.Conclusion There was an association between TPH A218C polymorphism and depression.The findings raise the possibility that TPH A218C polymorphism may exert differential effects based on gender.There is no association among TPH A218C polymorphism and symptom phenotypes of depression.
