The expression of survivin and P-gp proteins in epithelial ovarian carcinoma and its relationship with multidrug resistance in ovarian carcinoma
- VernacularTitle:P-糖蛋白、Survivin蛋白在卵巢上皮性癌中的表达及其与卵巢癌耐药的关系
- Author:
Qing GAO
;
Lanying XING
;
Yongxue WANG
- Publication Type:Journal Article
- Keywords:
ovarian neoplasm;
multidrug resistance;
P-gp;
survivin;
immunohistochemistry
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of inhibitor of apoptosis protein survivin and mdr1 gene protein P-gp in ovarian epithelial carcinoma,and analyze their functions of drug resistance in chemotherapy and the relationship with pathological characteristics.Methods We detected the expression of survivin and mdr1 proteins in 8 cases of normal ovarian tissues,16 cases of benign epithelial ovarian tumor tissues and 46 cases of epithelial ovarian cancerous tissues(28 cases of serous cystadenocarcinoma,12 cases of mucinous cystadenocarcinoma,and 6 cases of endometrioid carcinoma) with immunohistochemistry.Results The positive rate of survivin and mdr1 proteins in ovarian cancerous tissues was 60.9% and 34.8%,respectively,which was significantly higher than that in benign epithelial ovarian tumor tissues(31.3% and 0%) and normal ovarian tissues(negative)(P
