Expression and implication of Survivin and its correlation with p27～(kipl) in gallbladder cancer
- VernacularTitle:Survivin和p27~(kipl)在胆囊癌组织中的表达及相关性研究
- Author:
Zongli ZHANG
;
Jie CHAI
;
Demin MA
- Publication Type:Journal Article
- Keywords:
Gallbladder neoplasams?p27～(kipl)?Survivin?Immunohistochemistry
- From:Chinese Journal of Current Advances in General Surgery
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the expression of Survivin and p27～(kipl)and their relationship with the clinical features of gallbladder cancer.Methods:Fifty specimens of gallbladder cancer,20 specimens of chronic cholecystitis,20 specimens of polypoid lesions of gallbladder(PLG)were included,the expression of Survivin and p27～(kipl)were detected using immunohistochemistry assay.Results:In 50 cases of gallbladder cancer,39 cases expressed Survivin and 22 cases expressed p27～(kipl).There was a negative correlation between the expression of p27 and survivin(P0.05),but the expression of p27～(kipl)was related to the pathological grade,clinical stage and lymph node metastasis of gallbladder cancer(P
