Comparative Study on MRI Features and Pathology of Rabbit VX2 Hepatic Carcinoma
- VernacularTitle:兔VX_2肝癌MRI征象与病理对照研究
- Author:
Hongshun JIA
;
Xianyue QUAN
;
Tao SUN
- Publication Type:Journal Article
- Keywords:
MR imaging;
VX2;
liver;
pathology
- From:
Journal of Practical Radiology
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the pathologic bases of MRI manifestations of rabbit VX2 hepatic carcinoma.Methods 32 foci of hepatic carcinoma models in 20 rabbits VX2 were set up by implantation.Plain MR examinations in all rabbits and contrast-enhanced MR scan in 10 rabbits(15 foci) were performed 2~4 weeks after implantation.The largest transverse section specimens of all the tumors were obtained for imaging-pathology comparative study after MR scan.Results All the 32 tumors were detectable on both T1WI and T2WI.The size of the tumors ranged from 0.5 to 3.5 cm in diameter.6 foci showed homogeneous slight hyperintense on T2WI,the other 26 showed characteristic intratumoral signal intensity on T2WI,including "nodule in nodule"sign in 5 foci,"target"sign in 7 foci,and "dot and color"sign in 14 foci.The characteristic intratumoral signal showed on T2WI were pathologically testified as necrotic tumor tissue of different structures.All the 15 tumors with contrast-enhanced scan appeared annular enhancement in different degrees,slight enhancement in 6,medium enhancement in 7 and obvious enhancement in 2.The sinusoidlike vascular space between tumor cells were significantly dilated in the obvious enhancement cases,and there were many spots of necrosis in the slight enhancement tumors under microscope.Conclusion The tectology of intratumoral necrosis can be evaluated by T2WI.Enhanced degree after administration of contrast agent in the hepatic cancer in rabbit model is associated with dilating degrees of sinusoidlike vascular space and number of dotted necrosis of tumors.
