Effects of Formaldehyde on Learning,Memory and Activity of Antioxidase in Cerebral Tissues of Mice
- VernacularTitle:甲醛对小鼠的学习记忆及脑组织抗氧化酶的影响
- Author:
Aiping HU
;
Hongyu ZHOU
;
Xiaoyi QIN
- Publication Type:Journal Article
- Keywords:
Formaldehyde;
Learning and memory;
Watermaze;
Lipid peroxidation;
Superoxide dismutase
- From:
Journal of Environment and Health
2007;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of formaldehyde on learning and memory and the activity of superoxide dismutase (SOD) in the cerebral tissues. Methods 40 ICR mice were randomly divided into four gropes: A-control group (NS was added into water bottle), B, C, D-three formaldehyde dose groups (0.1, 0.2, 0.4% formaldehyde solution were added into water bottles). After 30 days of treatment, the ability of learning and memory were evaluated by Morris watermaze test and step-down test and the activity of SOD in the cerebral tissues was determined. Results In the Morris watermaze test (the fifth day), escapelaten latence in group C[ (29.23?5.56)s] and D[ (37.36?7.39)s] were significantly longer than group A[ (21.65?5.81)s](P
