Study on bioequivalence of two ranitidine
- Author:
Bui Tung Hiep
- Publication Type:Journal Article
- Keywords:
Ranitidine
- MeSH:
Ranitidine;
Therapeutic Equivalency;
Pharmaceutical Preparations
- From:Pharmaceutical Journal
2005;0(7):14-16
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Bioequivalents of two preparations composing of Ranitidine. A randomised crossover controlled single dose study was performed on 18 healthy volumteers (9 males and 5 females) aged from 22 to 40 years old. For each subject of each preparation 1 tablet composing of 150mg of ranitidine was administered orally. Plasma levels of ranitidine were evaluated by HPLC. The dissolution rate of different preparations showed that their properties were similar. Bioequivalent was evalnated statistacally (by diverse methods as ANOVA, confidence interval, West lke and Schurimann). No significant difference in plasma level of these 2 preparations was reforted. No side effect was noted
