Detection on the expression of PKC-? protein in lung cancer by tissue microarray
- VernacularTitle:组织芯片技术检测蛋白激酶C-?蛋白在肺癌组织中的表达
- Author:
Zhiqiang GAO
;
Xiaohua YANG
;
Jiuxian FENG
;
Baohui HAN
- Publication Type:Journal Article
- Keywords:
lung cancer;
protein kinase C-alpha;
tissue microarray;
immunohistochemistry
- From:China Oncology
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose:Protein kinase C (PKC) is a potentially important target for cancer therapy due to its potential role in carcinogenesis. Abnormal expression and increasing activity of PKC-?are present in non-small cell lung cancer (NSCLC).The aim of this study is to investigate PKC-? protein expressions in lung cancer tissues by tissue microarray and their significance. Methods:Using tissue microarray, PKC-? protein expression in lung cancer patients was examined by immunohistochemistry. 182 samples of umor tissues and 18 samples of adjacent tissues were taken;of the 182 samples, 160 were NSCLC tissues and 22 were SCLC;102 samples from stage I cases and 58 from stageⅡ-Ⅲ cases.Results:Expression of PKC-? protein was observed in 48.3% (88/182) of cancerous tissues and 16.7% (3/18) of adjacent tissues (P
