The relationship between neuroendocrine differentiated prostate carcinoma and drug-resistance to endocrine therapy
- VernacularTitle:前列腺癌神经内分泌化与内分泌治疗耐药的关系
- Author:
Jingwen WANG
;
Yang YAO
- Publication Type:Journal Article
- Keywords:
prostate carcinoma;
neuroendocrine differentiation;
drug resistance
- From:China Oncology
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Neuroendocrine cells comprise a minor subpopulation of the normal prostatic epithelium. When patients accept the androgen deprivation therapy, it will induce neuroendocrine differentiation of the prostate carcinoma cells. NE cells can provide endocrine/paracrine stimuli for proliferation of the surrounding carcinoma cells and inevitably make prostate cancer become androgen independent and no longer responsive to hormonal manipulation. In this paper, the mechanism of neuroendocrine differentiation and its relationship with androgen independent state were reviewed.
