Lymphomas with CARMA1, BCL10, MALT1 and NF-?B signaling pathway
- VernacularTitle:CARMA1-BCL10-MALT1,NF-?B信号传导通路与淋巴瘤
- Author:
Baizhou LI
;
Hongtao YE
;
Xiaoyan ZHOU
- Publication Type:Journal Article
- Keywords:
lymphoma;
CARMA1;
BCL10;
MALT1;
NF-?B;
signaling pathway
- From:
China Oncology
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
CARMA1, BCL10 and MALT1 are lymphocyte-specific signaling molecules of NF-?B pathway.The abnormalities of those molecules such as gene mutation, rearrangement, translocation or amplification often connect with the lymphoma genesis. This article reviewed the physiological function of those molecules and the relationship between genetic abnormalities and lymphoma genesis, also with present target-treatment research and new gene medicine development.
