The Association Between Urinary Albumin to Creatinine Ratio and Coronary Artery Calcification in Type 2 Diabetic Patients.
10.4093/kdj.2009.33.4.289
- Author:
Ju Young LEE
1
;
Yeon Kyung CHOI
;
Hyun Ae SEO
;
Jae Han JEON
;
Jung Eun LEE
;
Seong Su MOON
;
Jung Guk KIM
;
Bo Wan KIM
;
In Kyu LEE
Author Information
1. Department of Endocrinology and Metabolism, Kyungpook National University School of Medicine, Daegu, Korea. leei@mail.knu.ac.kr
- Publication Type:Original Article
- Keywords:
Albuminuria;
Coronary artery disease;
Type 2 diabetes mellitus
- MeSH:
Albuminuria;
Apolipoprotein A-I;
Atherosclerosis;
C-Reactive Protein;
Calcium;
Cardiovascular Diseases;
Cause of Death;
Coronary Artery Disease;
Coronary Vessels;
Creatinine;
Diabetes Mellitus, Type 2;
Humans;
Risk Factors
- From:Korean Diabetes Journal
2009;33(4):289-298
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Atherosclerosis, the most common cause of death in type 2 diabetic patients, is closely associated with coronary artery calcium deposition. The coronary calcifications can be easily measured using coronary calcium scoring computed tomography (CT). And microalbuminuria is known as an independent risk factor of cardiovascular disease. So, we examined the association of urinary albumin to creatinine ratio (UACR) and coronary calcification score (CCS) in type 2 diabetic patients. METHODS: Among type 2 diabetic patients who underwent the multidetector CT scanning for the evaluation of CCS at Kyungpook National University Hospital between December 2007 and May 2008, 155 subjects were included. CCS, demographic and laboratory data were assessed. RESULTS: Coronary artery calcifications were identified in 90 patients (51%) and mean, median CCS was 205.8 +/- 476.9, 8.74 (0, 132.0). 60 subjects revealed UACR greater than 30 ug/mg. With the UACR increment, CCS revealed a significant increase (P < 0.001). Age, duration of diabetes, serum Apo A1 level, serum high sensitivity C-reactive protein (hs-CRP) level were also associated with CCS. However, after adjusting for age, UACR and CCS exhibited a significant positive relationship (P = 0.002). CONCLUSION: Increased UACR is associated with coronary artery calcification in type 2 diabetic patients and these results will be useful in early evaluating the presence of macrovascular complications in these patients.
