Oxidative Damage on Testicles of Male Rats Induced by Micro-nano-scale SiO_2
- VernacularTitle:纳米级SiO_2对雄性大鼠睾丸组织的氧化损伤作用
- Author:
Bencheng LIN
;
Zhuge XI
;
Yingge ZHANG
- Publication Type:Journal Article
- Keywords:
Nano-silicon dioxide;
Micro-silicon dioxide;
Oxidative damage
- From:
Journal of Environment and Health
2007;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the oxidative damage on testis of male rats induced by micro-nano-scale SiO2. Methods Male Wistar rats were exposed to nanometer SiO2(20-40 nm) and micro-meter SiO2(1-10 ?m)by intratracheal injection once two days. The rats were killed after 5 weeks of exposure. Some indicators related to the oxidative damage in the serum and the testis were determined. Results The activity of GSH-Px and SOD in the high dose groups decreased significantly and the MDA levels increased compared to the control group;The MDA levels of nano-silicon dioxide high dose group increased in the serum. Conclusion Nano-silicon dioxide may cause lipid peroxidation in the testis with a tendency of higher toxicity than that of micro-SiO2 at the same exposed level,the detail mechanism needs further discussion.
