Joint Toxic Effect of Formaldehyde and Benzene on Testicles of Mice
- VernacularTitle:甲醛和苯联合染毒对雄性小鼠睾丸的毒性作用
- Author:
Xiaoli SHI
;
Fusheng YUAN
;
Zhihong ZHANG
- Publication Type:Journal Article
- Keywords:
Formaldehyde;
Benzene;
Testi;
Lipid peroxidation;
Superoxide dismutase;
Maleic dialdehyde;
Mice
- From:
Journal of Environment and Health
2007;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the joint toxic effect of formaldehyde and benzene on testicles of the mice. Methods 78 Kunming male mice were divided into groups, in the formaldehyde treatment groups were exposed at dosage of 0.2 mg/kg,2 mg/kg,20 mg/kg, in the benzene treatment groups were exposed at dosage of 100.0 mg/kg,200.0 mg/kg,400.0 mg/kg and the in formaldehyde and benzene combined treatment groups were exposed at dosage of 0.1+50.0 mg/kg,1+100.0 mg/kg,10+200.0 mg/kg respectively. The treatments were conducted by peritoneal injection for five consecutive days,once a day,then killed on 6th day. The activity of superoxide dismutase(SOD),the contents of maleic dialdehyde(MDA),the contents of copper(Cu),zinc(Zn) in testicles of the mice were determined. Results Compared with those in the negative control groups,the activity of SOD and the contents of Cu, Zn in the testicles of the mice in each treatment group significantly decreased, while the contents of MDA significantly increased (P
