The Combination of Fasting Plasma Glucose and Glycosylated Hemoglobin as a Predictor for Type 2 Diabetes in Korean Adults.
10.4093/kdj.2009.33.4.306
- Author:
Chan Hee LEE
1
;
Woo Jin CHANG
;
Hyun Hee CHUNG
;
Hyun Jung KIM
;
Sang Hyun PARK
;
Jun Sung MOON
;
Ji Eun LEE
;
Ji Sung YOON
;
Kyung Ah CHUN
;
Kyu Chang WON
;
Ihn Ho CHO
;
Hyoung Woo LEE
Author Information
1. Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, Korea. helee@med.yu.ac.kr
- Publication Type:Original Article
- Keywords:
Blood glucose;
Fasting;
Glycosylated hemoglobin A;
Type 2 diabetes mellitus
- MeSH:
Adult;
Asian Continental Ancestry Group;
Blood Glucose;
Cholesterol, HDL;
Diabetes Mellitus;
Diabetes Mellitus, Type 2;
Fasting;
Follow-Up Studies;
Glucose;
Glucose Tolerance Test;
Hemoglobin A, Glycosylated;
Hemoglobin, Sickle;
Humans;
Incidence;
Logistic Models;
Mass Screening;
Plasma
- From:Korean Diabetes Journal
2009;33(4):306-314
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The oral glucose tolerance test (OGTT) for detection of diabetes is difficult to perform in clinical settings. The aim of this study is to evaluate the performance of a more practical detection test, combined fasting plasma glucose (FPG) and glycosylated hemoglobin (HbA1c), as a predictor of diabetes mellitus (DM) in a Korean sample. METHODS: We examined 2,045 (M = 1,276, mean age = 47.8 +/- 9.0 yrs) medical check-up program participants between January 2002 to December 2003. FPG, HbA1c and a number of other biochemical tests were performed at baseline and four after years after initial screening. Patients who originally presented with diabetes were excluded. The characteristics of newly-diagnosed DM patients and non-diabetic patients were compared. RESULTS: The incidence of newly diagnosed diabetes was 1.6% (32/2,045) after four years of follow up. The subjects in the DM group were older, had higher levels of SBP, DBP, FPG, HbA1c, triglyceride, HDL cholesterol, GGT and LDH (P < 0.05). In multivariate logistic regression analysis, FPG (odds ratio [OR] 1.124) and HbA1c (OR 4.794) were significantly correlated with onset of diabetes (P < 0.05). The interaction parameter between FPG and HbA1c was more than 1.0, indicating that the two effects are synergistic. The predictive cut-off values of HbA1c and FPG were 5.35% (area under curve [AUC] = 0.944) and 102.5 mg/dL (AUC = 0.930), respectively. CONCLUSION: The combination of HbA1c above 5.35% and FPG above 102.5 mg/dL predicted the onset of diabetes in a Korean sample. These results suggest that the combination of FPG and HbA1c may be useful for predicting progression to type 2 diabetes in east Asians.
