The effect of Toll like receptor 4 and cytokines on the etiopathogenesis in the rat model with alcoholic liver disease
- VernacularTitle:Toll样受体4及细胞因子在酒精性肝病发病机理中的作用
- Author:
Junying ZHOU
;
Shukun YAO
;
Caiyan ZHAO
;
Zhen ZHEN
- Publication Type:Journal Article
- Keywords:
Alcoholic liver disease;
Toll like receptor 4;
Cytokine
- From:
Chinese Journal of Immunology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of Toll like receptor 4(TLR4) and interleukin 1 belta,6,10 and tumor necrosis ? on the etiopathogenesis in rat model with alcoholic liver disease(ALD).Methods:A rat model of ALD was induced by intragastric alcohol.At the end of 4,8,12 and 16 weeks,liver and serum samples were collected.The levels of interleukin 1 belta,6,10 and tumor necrosis ? in serum were examined.Hematoxylin-eosin,sudan Ⅳ and sirius red staining were performed to obeserve the hepatic pathology.The mRNA expression of TLR4 in liver tissues were examined by reverse transcription polymerase chain raction(RT-PCR) method.Results:With the progress of ALD,the levels of interleukin 1 belta,6 and tumor necrosis ? in serum and the mRNA expression of TLR4 in liver tissues increased significantly(P
