Primary observation on bone mesenchymal stem cells accelerating bone-tendon junction healing
- VernacularTitle:骨髓间充质干细胞促进骨-肌腱结合部愈合的初步观察
- Author:
Fei DONG
;
Honghui CHEN
;
Xiaohong YANG
- Publication Type:Journal Article
- Keywords:
bone mesenchymal stem cells;
bone-tendon junction;
healing
- From:
Orthopedic Journal of China
2006;0(16):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To evaluate tho effects of Bone Mesenchymal Stem Cells(BMSCs) on healing of bone-tendon junction in a patellar tendon complex.[Method]The BMSCs of rabbits were harvested by bone marrow aspiration. Adherent cells were selected as BMSCs after the whole marrow was cultured.Standard partial patellectomy was conducted in 36 18-week-old rabbits divided into 2 groups. The experimental group was planted into by the composite of BMSCs and Pluronic F-127 while the control group was only operated without BMSCs planting into.The patellar-patellar tendon complexes were harvested at weeks 6,12,18 postoperatively for radiographic, gross and histological evaluations.[Result]Radiographic measurements showed significantly more newly formed bone at the patellar tendon-patellar healing junction in the experimental group compared with that of the controls at weeks 6,12,18(P
